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PTDSS1

PTDSS1(磷脂酰絲氨酸合成酶1)是細胞內(nèi)磷脂代謝的關(guān)鍵酶,也被稱為PSS1或PTDSS。該蛋白通過催化絲氨酸與CDP-二酰基甘油的結(jié)合反應(yīng),在內(nèi)質(zhì)網(wǎng)中合成磷脂酰絲氨酸(PS),后者是細胞膜的重要組分。PS不僅參與膜結(jié)構(gòu)的動態(tài)平衡,還在凋亡細胞表面暴露時觸發(fā)免疫清除信號,并與凝血因子活化、突觸可塑性等生理過程相關(guān)。近年來研究發(fā)現(xiàn),PTDSS1基因突變與遺傳性小腦共濟失調(diào)2型(SCA2)及Lenz-Majewski綜合征相關(guān),其表達異常可能影響神經(jīng)細胞膜穩(wěn)定性。在腫瘤領(lǐng)域,PTDSS1過表達被證實通過改變細胞膜磷脂組成促進肝癌、乳腺癌侵襲轉(zhuǎn)移。針對該靶點的藥物研發(fā)尚處早期,已有研究嘗試利用小分子抑制劑干擾PS合成通路,或通過調(diào)控PTDSS1表達增強化療藥物敏感性。2021年《自然·化學(xué)生物學(xué)》報道了首個選擇性靶向PTDSS1的化合物探針,為相關(guān)疾病治療提供了新思路。

熱銷產(chǎn)品

Recombinant Human Phosphatidylserine synthase 1 (PTDSS1), partial (CSB-RP043054h)

驗證數(shù)據(jù)

CSB-RP043054h

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PTDSS1 Antibody (CSB-PA04305A0Rb)

驗證數(shù)據(jù)

CSB-PA04305A0Rb

Western Blot
Positive WB detected in: 293T whole cell lysate(20μg), K562 whole cell lysate(20μg), HepG2 whole cell lysate(20μg), MCF7 whole cell lysate(20μg
All lanes: PTDSS1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/20000 dilution
Predicted band size: 56,39,35 kDa
Observed band size: 35 kDa
Exposure time: 60s

CSB-PA04305A0Rb

IHC image of CSB-PA04305A0Rb diluted at 1:150 and staining in paraffin-embedded humanpancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody

PTDSS1 Antibodies

PTDSS1 for Homo sapiens (Human)

PTDSS1 Proteins

PTDSS1 Proteins for Homo sapiens (Human)